PhytophthoraV1, Main, Exploration, bibRecord, 000A09

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

Identifieur interne : 000A09 ( Main/Exploration ); précédent : 000A08; suivant : 000A10

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

Auteurs : Tea Lenar I [Slovénie] ; Isabell Albert [Allemagne] ; Hannah Böhm [Allemagne] ; Vesna Hodnik [Slovénie] ; Katja Pirc [Slovénie] ; Apolonija B. Zavec [Slovénie] ; Marjetka Podobnik [Slovénie] ; David Pahovnik [Slovénie] ; Ema Žagar [Slovénie] ; Rory Pruitt [Allemagne] ; Peter Greimel [Japon] ; Akiko Yamaji-Hasegawa [Japon] ; Toshihide Kobayashi [Japon, France] ; Agnieszka Zienkiewicz [Allemagne] ; Jasmin Gömann [Allemagne] ; Jenny C. Mortimer [États-Unis] ; Lin Fang [États-Unis] ; Adiilah Mamode-Cassim [France] ; Magali Deleu [Belgique] ; Laurence Lins [Belgique] ; Claudia Oecking [Allemagne] ; Ivo Feussner [Allemagne] ; Sébastien Mongrand [France] ; Gregor Anderluh [Slovénie] ; Thorsten Nürnberger [Allemagne]

Source :

Science (New York, N.Y.) [ 1095-9203 ] ; 2017.

RBID : pubmed:29242345

Descripteurs français

KwdFr :
- Arabidopsis (parasitologie), Cristallographie aux rayons X (MeSH), Cytotoxines (composition chimique), Cytotoxines (métabolisme), Maladies des plantes (parasitologie), Phytophthora (métabolisme), Pythium (métabolisme), Sites de fixation (MeSH), Sphingolipides (composition chimique), Sphingolipides (métabolisme), Spécificité d'hôte (MeSH), Toxines biologiques (métabolisme), Éthylènes (métabolisme).
MESH :
- composition chimique : Cytotoxines, Sphingolipides.
- métabolisme : Cytotoxines, Phytophthora, Pythium, Sphingolipides, Toxines biologiques, Éthylènes.
- parasitologie : Arabidopsis, Maladies des plantes.
- Cristallographie aux rayons X, Sites de fixation, Spécificité d'hôte.

English descriptors

KwdEn :
- Arabidopsis (parasitology), Binding Sites (MeSH), Crystallography, X-Ray (MeSH), Cytotoxins (chemistry), Cytotoxins (metabolism), Ethylenes (metabolism), Host Specificity (MeSH), Phytophthora (metabolism), Plant Diseases (parasitology), Pythium (metabolism), Sphingolipids (chemistry), Sphingolipids (metabolism), Toxins, Biological (metabolism).
MESH :
- chemical , chemistry : Cytotoxins, Sphingolipids.
- chemical , metabolism : Cytotoxins, Ethylenes, Sphingolipids, Toxins, Biological.
- metabolism : Phytophthora, Pythium.
- parasitology : Arabidopsis, Plant Diseases.
- Binding Sites, Crystallography, X-Ray, Host Specificity.

Abstract

Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity.

DOI: 10.1126/science.aan6874
PubMed: 29242345

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000864
to stream Main, to step Curation: 000864

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.</title>
<author><name sortKey="Lenar I, Tea" sort="Lenar I, Tea" uniqKey="Lenar I T" first="Tea" last="Lenar I">Tea Lenar I</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albert, Isabell" sort="Albert, Isabell" uniqKey="Albert I" first="Isabell" last="Albert">Isabell Albert</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bohm, Hannah" sort="Bohm, Hannah" uniqKey="Bohm H" first="Hannah" last="Böhm">Hannah Böhm</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hodnik, Vesna" sort="Hodnik, Vesna" uniqKey="Hodnik V" first="Vesna" last="Hodnik">Vesna Hodnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirc, Katja" sort="Pirc, Katja" uniqKey="Pirc K" first="Katja" last="Pirc">Katja Pirc</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zavec, Apolonija B" sort="Zavec, Apolonija B" uniqKey="Zavec A" first="Apolonija B" last="Zavec">Apolonija B. Zavec</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Podobnik, Marjetka" sort="Podobnik, Marjetka" uniqKey="Podobnik M" first="Marjetka" last="Podobnik">Marjetka Podobnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pahovnik, David" sort="Pahovnik, David" uniqKey="Pahovnik D" first="David" last="Pahovnik">David Pahovnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zagar, Ema" sort="Zagar, Ema" uniqKey="Zagar E" first="Ema" last="Žagar">Ema Žagar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pruitt, Rory" sort="Pruitt, Rory" uniqKey="Pruitt R" first="Rory" last="Pruitt">Rory Pruitt</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Greimel, Peter" sort="Greimel, Peter" uniqKey="Greimel P" first="Peter" last="Greimel">Peter Greimel</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Saitama 351-0198</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamaji Hasegawa, Akiko" sort="Yamaji Hasegawa, Akiko" uniqKey="Yamaji Hasegawa A" first="Akiko" last="Yamaji-Hasegawa">Akiko Yamaji-Hasegawa</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Saitama 351-0198</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Toshihide" sort="Kobayashi, Toshihide" uniqKey="Kobayashi T" first="Toshihide" last="Kobayashi">Toshihide Kobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Illkirch</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zienkiewicz, Agnieszka" sort="Zienkiewicz, Agnieszka" uniqKey="Zienkiewicz A" first="Agnieszka" last="Zienkiewicz">Agnieszka Zienkiewicz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gomann, Jasmin" sort="Gomann, Jasmin" uniqKey="Gomann J" first="Jasmin" last="Gömann">Jasmin Gömann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mortimer, Jenny C" sort="Mortimer, Jenny C" uniqKey="Mortimer J" first="Jenny C" last="Mortimer">Jenny C. Mortimer</name>
<affiliation wicri:level="2"><nlm:affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Joint Bioenergy Institute, Emeryville, CA 94608</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fang, Lin" sort="Fang, Lin" uniqKey="Fang L" first="Lin" last="Fang">Lin Fang</name>
<affiliation wicri:level="2"><nlm:affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Joint Bioenergy Institute, Emeryville, CA 94608</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mamode Cassim, Adiilah" sort="Mamode Cassim, Adiilah" uniqKey="Mamode Cassim A" first="Adiilah" last="Mamode-Cassim">Adiilah Mamode-Cassim</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Villenave-d'Ornon</settlement>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Deleu, Magali" sort="Deleu, Magali" uniqKey="Deleu M" first="Magali" last="Deleu">Magali Deleu</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux</wicri:regionArea>
<orgName type="university">Université de Liège</orgName>
<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lins, Laurence" sort="Lins, Laurence" uniqKey="Lins L" first="Laurence" last="Lins">Laurence Lins</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux</wicri:regionArea>
<orgName type="university">Université de Liège</orgName>
<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oecking, Claudia" sort="Oecking, Claudia" uniqKey="Oecking C" first="Claudia" last="Oecking">Claudia Oecking</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feussner, Ivo" sort="Feussner, Ivo" uniqKey="Feussner I" first="Ivo" last="Feussner">Ivo Feussner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mongrand, Sebastien" sort="Mongrand, Sebastien" uniqKey="Mongrand S" first="Sébastien" last="Mongrand">Sébastien Mongrand</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Villenave-d'Ornon</settlement>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Anderluh, Gregor" sort="Anderluh, Gregor" uniqKey="Anderluh G" first="Gregor" last="Anderluh">Gregor Anderluh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:29242345</idno>
<idno type="pmid">29242345</idno>
<idno type="doi">10.1126/science.aan6874</idno>
<idno type="wicri:Area/Main/Corpus">000864</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000864</idno>
<idno type="wicri:Area/Main/Curation">000864</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000864</idno>
<idno type="wicri:Area/Main/Exploration">000864</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.</title>
<author><name sortKey="Lenar I, Tea" sort="Lenar I, Tea" uniqKey="Lenar I T" first="Tea" last="Lenar I">Tea Lenar I</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albert, Isabell" sort="Albert, Isabell" uniqKey="Albert I" first="Isabell" last="Albert">Isabell Albert</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bohm, Hannah" sort="Bohm, Hannah" uniqKey="Bohm H" first="Hannah" last="Böhm">Hannah Böhm</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hodnik, Vesna" sort="Hodnik, Vesna" uniqKey="Hodnik V" first="Vesna" last="Hodnik">Vesna Hodnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirc, Katja" sort="Pirc, Katja" uniqKey="Pirc K" first="Katja" last="Pirc">Katja Pirc</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zavec, Apolonija B" sort="Zavec, Apolonija B" uniqKey="Zavec A" first="Apolonija B" last="Zavec">Apolonija B. Zavec</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Podobnik, Marjetka" sort="Podobnik, Marjetka" uniqKey="Podobnik M" first="Marjetka" last="Podobnik">Marjetka Podobnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pahovnik, David" sort="Pahovnik, David" uniqKey="Pahovnik D" first="David" last="Pahovnik">David Pahovnik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zagar, Ema" sort="Zagar, Ema" uniqKey="Zagar E" first="Ema" last="Žagar">Ema Žagar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pruitt, Rory" sort="Pruitt, Rory" uniqKey="Pruitt R" first="Rory" last="Pruitt">Rory Pruitt</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Greimel, Peter" sort="Greimel, Peter" uniqKey="Greimel P" first="Peter" last="Greimel">Peter Greimel</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Saitama 351-0198</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamaji Hasegawa, Akiko" sort="Yamaji Hasegawa, Akiko" uniqKey="Yamaji Hasegawa A" first="Akiko" last="Yamaji-Hasegawa">Akiko Yamaji-Hasegawa</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Saitama 351-0198</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Toshihide" sort="Kobayashi, Toshihide" uniqKey="Kobayashi T" first="Toshihide" last="Kobayashi">Toshihide Kobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198</wicri:regionArea>
<wicri:noRegion>Wako Saitama 351-0198</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Illkirch</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zienkiewicz, Agnieszka" sort="Zienkiewicz, Agnieszka" uniqKey="Zienkiewicz A" first="Agnieszka" last="Zienkiewicz">Agnieszka Zienkiewicz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gomann, Jasmin" sort="Gomann, Jasmin" uniqKey="Gomann J" first="Jasmin" last="Gömann">Jasmin Gömann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mortimer, Jenny C" sort="Mortimer, Jenny C" uniqKey="Mortimer J" first="Jenny C" last="Mortimer">Jenny C. Mortimer</name>
<affiliation wicri:level="2"><nlm:affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Joint Bioenergy Institute, Emeryville, CA 94608</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fang, Lin" sort="Fang, Lin" uniqKey="Fang L" first="Lin" last="Fang">Lin Fang</name>
<affiliation wicri:level="2"><nlm:affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Joint Bioenergy Institute, Emeryville, CA 94608</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mamode Cassim, Adiilah" sort="Mamode Cassim, Adiilah" uniqKey="Mamode Cassim A" first="Adiilah" last="Mamode-Cassim">Adiilah Mamode-Cassim</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Villenave-d'Ornon</settlement>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Deleu, Magali" sort="Deleu, Magali" uniqKey="Deleu M" first="Magali" last="Deleu">Magali Deleu</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux</wicri:regionArea>
<orgName type="university">Université de Liège</orgName>
<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lins, Laurence" sort="Lins, Laurence" uniqKey="Lins L" first="Laurence" last="Lins">Laurence Lins</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux</wicri:regionArea>
<orgName type="university">Université de Liège</orgName>
<placeName><settlement type="city">Liège</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province de Liège</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oecking, Claudia" sort="Oecking, Claudia" uniqKey="Oecking C" first="Claudia" last="Oecking">Claudia Oecking</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feussner, Ivo" sort="Feussner, Ivo" uniqKey="Feussner I" first="Ivo" last="Feussner">Ivo Feussner</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Göttingen Center for Molecular Biosciences, University of Göttingen</wicri:regionArea>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
<wicri:noRegion>University of Göttingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mongrand, Sebastien" sort="Mongrand, Sebastien" uniqKey="Mongrand S" first="Sébastien" last="Mongrand">Sébastien Mongrand</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Villenave-d'Ornon</settlement>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Anderluh, Gregor" sort="Anderluh, Gregor" uniqKey="Anderluh G" first="Gregor" last="Anderluh">Gregor Anderluh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana</wicri:regionArea>
<wicri:noRegion>1000 Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Science (New York, N.Y.)</title>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabidopsis (parasitology)</term>
<term>Binding Sites (MeSH)</term>
<term>Crystallography, X-Ray (MeSH)</term>
<term>Cytotoxins (chemistry)</term>
<term>Cytotoxins (metabolism)</term>
<term>Ethylenes (metabolism)</term>
<term>Host Specificity (MeSH)</term>
<term>Phytophthora (metabolism)</term>
<term>Plant Diseases (parasitology)</term>
<term>Pythium (metabolism)</term>
<term>Sphingolipids (chemistry)</term>
<term>Sphingolipids (metabolism)</term>
<term>Toxins, Biological (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Arabidopsis (parasitologie)</term>
<term>Cristallographie aux rayons X (MeSH)</term>
<term>Cytotoxines (composition chimique)</term>
<term>Cytotoxines (métabolisme)</term>
<term>Maladies des plantes (parasitologie)</term>
<term>Phytophthora (métabolisme)</term>
<term>Pythium (métabolisme)</term>
<term>Sites de fixation (MeSH)</term>
<term>Sphingolipides (composition chimique)</term>
<term>Sphingolipides (métabolisme)</term>
<term>Spécificité d'hôte (MeSH)</term>
<term>Toxines biologiques (métabolisme)</term>
<term>Éthylènes (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cytotoxins</term>
<term>Sphingolipids</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytotoxins</term>
<term>Ethylenes</term>
<term>Sphingolipids</term>
<term>Toxins, Biological</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Cytotoxines</term>
<term>Sphingolipides</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phytophthora</term>
<term>Pythium</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytotoxines</term>
<term>Phytophthora</term>
<term>Pythium</term>
<term>Sphingolipides</term>
<term>Toxines biologiques</term>
<term>Éthylènes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Arabidopsis</term>
<term>Maladies des plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Arabidopsis</term>
<term>Plant Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term>
<term>Crystallography, X-Ray</term>
<term>Host Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cristallographie aux rayons X</term>
<term>Sites de fixation</term>
<term>Spécificité d'hôte</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29242345</PMID>
<DateCompleted><Year>2018</Year>
<Month>01</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>01</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>358</Volume>
<Issue>6369</Issue>
<PubDate><Year>2017</Year>
<Month>12</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Science (New York, N.Y.)</Title>
<ISOAbbreviation>Science</ISOAbbreviation>
</Journal>
<ArticleTitle>Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.</ArticleTitle>
<Pagination><MedlinePgn>1431-1434</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1126/science.aan6874</ELocationID>
<Abstract><AbstractText>Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity.</AbstractText>
<CopyrightInformation>Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lenarčič</LastName>
<ForeName>Tea</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0003-2590-0323</Identifier>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Albert</LastName>
<ForeName>Isabell</ForeName>
<Initials>I</Initials>
<Identifier Source="ORCID">0000-0003-2223-496X</Identifier>
<AffiliationInfo><Affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Böhm</LastName>
<ForeName>Hannah</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">0000-0002-0932-332X</Identifier>
<AffiliationInfo><Affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hodnik</LastName>
<ForeName>Vesna</ForeName>
<Initials>V</Initials>
<Identifier Source="ORCID">0000-0002-7681-038X</Identifier>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pirc</LastName>
<ForeName>Katja</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zavec</LastName>
<ForeName>Apolonija B</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Podobnik</LastName>
<ForeName>Marjetka</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0001-6786-9737</Identifier>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pahovnik</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">0000-0001-8024-8871</Identifier>
<AffiliationInfo><Affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Žagar</LastName>
<ForeName>Ema</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">0000-0002-2694-4312</Identifier>
<AffiliationInfo><Affiliation>Department of Polymer Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pruitt</LastName>
<ForeName>Rory</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Greimel</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamaji-Hasegawa</LastName>
<ForeName>Akiko</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Molecular Membrane Neuroscience, Brain Science Institute, RIKEN Institute, Wako, Saitama 351-0198, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kobayashi</LastName>
<ForeName>Toshihide</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Lipid Biology Laboratory, RIKEN, Wako Saitama 351-0198, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR 7213 CNRS, University of Strasbourg, 67401 Illkirch, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zienkiewicz</LastName>
<ForeName>Agnieszka</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0003-0799-0521</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gömann</LastName>
<ForeName>Jasmin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mortimer</LastName>
<ForeName>Jenny C</ForeName>
<Initials>JC</Initials>
<Identifier Source="ORCID">0000-0001-6624-636X</Identifier>
<AffiliationInfo><Affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fang</LastName>
<ForeName>Lin</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0002-9971-4569</Identifier>
<AffiliationInfo><Affiliation>Joint Bioenergy Institute, Emeryville, CA 94608, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mamode-Cassim</LastName>
<ForeName>Adiilah</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deleu</LastName>
<ForeName>Magali</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0001-8255-2965</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lins</LastName>
<ForeName>Laurence</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0001-7772-6748</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Molecular Biophysics at Interfaces, University of Liège, Gembloux, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oecking</LastName>
<ForeName>Claudia</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">0000-0003-0635-6457</Identifier>
<AffiliationInfo><Affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feussner</LastName>
<ForeName>Ivo</ForeName>
<Initials>I</Initials>
<Identifier Source="ORCID">0000-0002-9888-7003</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Göttingen Center for Molecular Biosciences, University of Göttingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mongrand</LastName>
<ForeName>Sébastien</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0002-9198-015X</Identifier>
<AffiliationInfo><Affiliation>Laboratoire de Biogenèse Membranaire, UMR 5200 CNRS-Université de Bordeaux, 71 Avenue Edouard Bourlaux, 33883 Villenave-d'Ornon Cedex, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderluh</LastName>
<ForeName>Gregor</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0002-9916-8465</Identifier>
<AffiliationInfo><Affiliation>Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nürnberger</LastName>
<ForeName>Thorsten</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0003-3992-0149</Identifier>
<AffiliationInfo><Affiliation>Centre of Plant Molecular Biology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany. gregor.anderluh@ki.si nuernberger@uni-tuebingen.de.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Science</MedlineTA>
<NlmUniqueID>0404511</NlmUniqueID>
<ISSNLinking>0036-8075</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D003603">Cytotoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005030">Ethylenes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013107">Sphingolipids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014118">Toxins, Biological</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>91GW059KN7</RegistryNumber>
<NameOfSubstance UI="C036216">ethylene</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Science. 2017 Dec 15;358(6369):1383-1384</RefSource>
<PMID Version="1">29242331</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018360" MajorTopicYN="N">Crystallography, X-Ray</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003603" MajorTopicYN="N">Cytotoxins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005030" MajorTopicYN="N">Ethylenes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058507" MajorTopicYN="Y">Host Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011775" MajorTopicYN="N">Pythium</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013107" MajorTopicYN="N">Sphingolipids</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014118" MajorTopicYN="N">Toxins, Biological</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>05</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>10</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>12</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>12</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>1</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29242345</ArticleId>
<ArticleId IdType="pii">358/6369/1431</ArticleId>
<ArticleId IdType="doi">10.1126/science.aan6874</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>France</li>
<li>Japon</li>
<li>Slovénie</li>
<li>États-Unis</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Aquitaine</li>
<li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>District de Tübingen</li>
<li>Grand Est</li>
<li>Nouvelle-Aquitaine</li>
<li>Province de Liège</li>
<li>Région wallonne</li>
</region>
<settlement><li>Illkirch</li>
<li>Liège</li>
<li>Tübingen</li>
<li>Villenave-d'Ornon</li>
</settlement>
<orgName><li>Université de Bordeaux</li>
<li>Université de Liège</li>
</orgName>
</list>
<tree><country name="Slovénie"><noRegion><name sortKey="Lenar I, Tea" sort="Lenar I, Tea" uniqKey="Lenar I T" first="Tea" last="Lenar I">Tea Lenar I</name>
</noRegion>
<name sortKey="Anderluh, Gregor" sort="Anderluh, Gregor" uniqKey="Anderluh G" first="Gregor" last="Anderluh">Gregor Anderluh</name>
<name sortKey="Hodnik, Vesna" sort="Hodnik, Vesna" uniqKey="Hodnik V" first="Vesna" last="Hodnik">Vesna Hodnik</name>
<name sortKey="Hodnik, Vesna" sort="Hodnik, Vesna" uniqKey="Hodnik V" first="Vesna" last="Hodnik">Vesna Hodnik</name>
<name sortKey="Pahovnik, David" sort="Pahovnik, David" uniqKey="Pahovnik D" first="David" last="Pahovnik">David Pahovnik</name>
<name sortKey="Pirc, Katja" sort="Pirc, Katja" uniqKey="Pirc K" first="Katja" last="Pirc">Katja Pirc</name>
<name sortKey="Podobnik, Marjetka" sort="Podobnik, Marjetka" uniqKey="Podobnik M" first="Marjetka" last="Podobnik">Marjetka Podobnik</name>
<name sortKey="Zagar, Ema" sort="Zagar, Ema" uniqKey="Zagar E" first="Ema" last="Žagar">Ema Žagar</name>
<name sortKey="Zavec, Apolonija B" sort="Zavec, Apolonija B" uniqKey="Zavec A" first="Apolonija B" last="Zavec">Apolonija B. Zavec</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Albert, Isabell" sort="Albert, Isabell" uniqKey="Albert I" first="Isabell" last="Albert">Isabell Albert</name>
</region>
<name sortKey="Bohm, Hannah" sort="Bohm, Hannah" uniqKey="Bohm H" first="Hannah" last="Böhm">Hannah Böhm</name>
<name sortKey="Feussner, Ivo" sort="Feussner, Ivo" uniqKey="Feussner I" first="Ivo" last="Feussner">Ivo Feussner</name>
<name sortKey="Feussner, Ivo" sort="Feussner, Ivo" uniqKey="Feussner I" first="Ivo" last="Feussner">Ivo Feussner</name>
<name sortKey="Gomann, Jasmin" sort="Gomann, Jasmin" uniqKey="Gomann J" first="Jasmin" last="Gömann">Jasmin Gömann</name>
<name sortKey="Gomann, Jasmin" sort="Gomann, Jasmin" uniqKey="Gomann J" first="Jasmin" last="Gömann">Jasmin Gömann</name>
<name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name>
<name sortKey="Oecking, Claudia" sort="Oecking, Claudia" uniqKey="Oecking C" first="Claudia" last="Oecking">Claudia Oecking</name>
<name sortKey="Pruitt, Rory" sort="Pruitt, Rory" uniqKey="Pruitt R" first="Rory" last="Pruitt">Rory Pruitt</name>
<name sortKey="Zienkiewicz, Agnieszka" sort="Zienkiewicz, Agnieszka" uniqKey="Zienkiewicz A" first="Agnieszka" last="Zienkiewicz">Agnieszka Zienkiewicz</name>
<name sortKey="Zienkiewicz, Agnieszka" sort="Zienkiewicz, Agnieszka" uniqKey="Zienkiewicz A" first="Agnieszka" last="Zienkiewicz">Agnieszka Zienkiewicz</name>
</country>
<country name="Japon"><noRegion><name sortKey="Greimel, Peter" sort="Greimel, Peter" uniqKey="Greimel P" first="Peter" last="Greimel">Peter Greimel</name>
</noRegion>
<name sortKey="Greimel, Peter" sort="Greimel, Peter" uniqKey="Greimel P" first="Peter" last="Greimel">Peter Greimel</name>
<name sortKey="Kobayashi, Toshihide" sort="Kobayashi, Toshihide" uniqKey="Kobayashi T" first="Toshihide" last="Kobayashi">Toshihide Kobayashi</name>
<name sortKey="Yamaji Hasegawa, Akiko" sort="Yamaji Hasegawa, Akiko" uniqKey="Yamaji Hasegawa A" first="Akiko" last="Yamaji-Hasegawa">Akiko Yamaji-Hasegawa</name>
<name sortKey="Yamaji Hasegawa, Akiko" sort="Yamaji Hasegawa, Akiko" uniqKey="Yamaji Hasegawa A" first="Akiko" last="Yamaji-Hasegawa">Akiko Yamaji-Hasegawa</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Kobayashi, Toshihide" sort="Kobayashi, Toshihide" uniqKey="Kobayashi T" first="Toshihide" last="Kobayashi">Toshihide Kobayashi</name>
</region>
<name sortKey="Mamode Cassim, Adiilah" sort="Mamode Cassim, Adiilah" uniqKey="Mamode Cassim A" first="Adiilah" last="Mamode-Cassim">Adiilah Mamode-Cassim</name>
<name sortKey="Mongrand, Sebastien" sort="Mongrand, Sebastien" uniqKey="Mongrand S" first="Sébastien" last="Mongrand">Sébastien Mongrand</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Mortimer, Jenny C" sort="Mortimer, Jenny C" uniqKey="Mortimer J" first="Jenny C" last="Mortimer">Jenny C. Mortimer</name>
</region>
<name sortKey="Fang, Lin" sort="Fang, Lin" uniqKey="Fang L" first="Lin" last="Fang">Lin Fang</name>
<name sortKey="Fang, Lin" sort="Fang, Lin" uniqKey="Fang L" first="Lin" last="Fang">Lin Fang</name>
<name sortKey="Mortimer, Jenny C" sort="Mortimer, Jenny C" uniqKey="Mortimer J" first="Jenny C" last="Mortimer">Jenny C. Mortimer</name>
</country>
<country name="Belgique"><region name="Région wallonne"><name sortKey="Deleu, Magali" sort="Deleu, Magali" uniqKey="Deleu M" first="Magali" last="Deleu">Magali Deleu</name>
</region>
<name sortKey="Lins, Laurence" sort="Lins, Laurence" uniqKey="Lins L" first="Laurence" last="Lins">Laurence Lins</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PhytophthoraV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A09 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A09 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    PhytophthoraV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29242345
   |texte=   Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29242345" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PhytophthoraV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Nov 20 11:20:57 2020. Site generation: Wed Mar 6 16:48:20 2024

	Serveur d'exploration Phytophthora
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Phytophthora

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki